Trk Receptor
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Trk Receptor Inhibitors
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Trk Receptor Agonists
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Trk Receptor Antagonists
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Trk Receptor Activators
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Trk Receptor Modulators
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Trk Receptor Degraders
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Trk Receptor Control
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Trk Receptor Related Products (116)
Related Products (116)
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Anti-TrkB/NTRK2 Antibody
0 ImagesCat. No.: HY-P991098
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TrkA-IN-7
0 ImagesCat. No.: HY-169546CAS No.: 296888-45-4TrkA-IN-7 (Compound 4) is an inhibitor of Tropomyosin Receptor Kinase A (TrkA) with a Kd value of 40 μM.
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N-Acetyl-5-hydroxytryptamine (Standard)
0 ImagesSynonyms: N-Acetylserotonin (Standard); Normelatonin (Standard); O-Demethylmelatonin (Standard)N-Acetyl-5-hydroxytryptamine (Standard) is the analytical standard of N-Acetyl-5-hydroxytryptamine. This product is intended for research and analytical applications. N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.
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TRKA G667C Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70785TRKA is a member of the tropomyosin receptor kinase (TRK) family, and its primary binding ligand is nerve growth factor (NGF). TRKA G667C is a mutant of TRKA. TRKA G667C Recombinant Human Active Protein Kinase is a recombinant TRKA G667C protein that can be used to study TRKA G667C-related functions.
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Trk-IN-6
0 ImagesCat. No.: HY-139891CAS No.: 2489327-43-5Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants (IC50 = 0.2-0.7 nM).
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Anti-NGF2 Antibody
0 ImagesCat. No.: HY-P992273
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(R,S)-Selitrectinib
0 ImagesCat. No.: HY-101977ACAS No.: 2097002-59-8Synonyms: (R,S)-LOXO-195
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Larotrectinib-d4
0 ImagesCat. No.: HY-12866S1Synonyms: LOXO-101-d4; ARRY-470-d4Larotrectinib-d4 (LOXO-101-d4) is the deuterium labeled Larotrectinib (HY-12866). Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
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TRK-IN-27
0 ImagesCat. No.: HY-161179CAS No.: 3032924-03-8TRK-IN-27 (Compound 14q) is a potent TRK inhibitor with good kinase selectivity. TRK-IN-27 effectively inhibits tumor growth.
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TRK-IN-12
0 ImagesCat. No.: HY-144451CAS No.: 2823342-34-1TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line.
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CRB-0089
0 ImagesCat. No.: HY-P991325CRB-0089 is a human monoclonal antibody (mAb) targeting NGF/bNGF. CRB-0089 can be used in analgesia research.
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Antitumor agent-223
0 ImagesCat. No.: HY-184729CAS No.: 3124621-78-6Antitumor agent-223 is an anticancer agent and TRK inhibitor. Antitumor agent-223 exerts potent antitumor activity against liver cancer and breast cancer. Antitumor agent-223 can be used for the research of hepatocellular carcinoma and breast cancer.
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TRK-IN-18
0 ImagesCat. No.: HY-146524CAS No.: 2412008-91-2TRK-IN-18 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-18 has the potential for the research of cancer diseases (extracted from patent WO2021148805A1, compound 7).
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PC-046
0 ImagesCat. No.: HY-120561CAS No.: 1202401-59-9PC-046 is a multi-target inhibitor for tyrosine receptor kinase B (TrkB), IRAK-4 and Pim-1, with IC50 of 13.4 μM, 15.4 μM and 19.1 μM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice.
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2-Bromo-6-methoxynaphthalene (Standard)
0 Images2-Bromo-6-methoxynaphthalene (Standard) is the analytical standard of 2-Bromo-6-methoxynaphthalene. This product is intended for research and analytical applications. 2-Bromo-6-methoxynaphthalene is an active intermediate in the production of anti-inflammatory agents like Naproxen and Nabumetone by Heck reaction. 2-Bromo-6-methoxynaphthalene has potential anti-inflammatory properties and Tyrosine-protein inhibitor properties. 2-Bromo-6-methoxynaphthalene can be used for the research of cancer.
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Longanlactone
0 ImagesCat. No.: HY-124503CAS No.: 1438721-51-7Longanlactone is a natural pyrrole-lactone alkaloid that can be used as a neurotrophic agent. Longanlactone increases BDNF gene expression in neuro2a cells.
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Utatrectinib (Standard)
0 ImagesCat. No.: HY-102066RCAS No.: 1079274-94-4Synonyms: AZD-7451 (Standard)Utatrectinib (Standard) is the analytical standard of Utatrectinib (HY-102066). This product is intended for research and analytical applications. Utatrectinib (AZD-7451) is a potent, selective and orally active Trk inhibitor. Utatrectinib blocks TrkC activation and associated tumorigenic behaviors.
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PD 90780 (Standard)
0 ImagesCat. No.: HY-110166RCAS No.: 77422-99-2PD 90780 (Standard) is the analytical standard of PD 90780 (HY-110166). This product is intended for research and analytical applications. PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively .
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(3aR)-Selitrectinib
0 ImagesCat. No.: HY-101977BCAS No.: 1350884-56-8Synonyms: (3aR)-LOXO-195(3aR)-Selitrectinib ((3aR)-LOXO-195) is an isform of Selitrectinib (HY-101977), which is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively.
